© 2007 Wang Lijun (1 of 1)
Distribution and Habitat
Country distribution from AmphibiaWeb's database: China, India, Lao People's Democratic Republic, Myanmar, Thailand, Viet Nam
January 29, 2018: Cathelicidins are a family polypeptides, known for their antimicrobial properties, that are found in immune and skin cells. About 30 cationic peptides have been isolated in various vertebrates. However, despite amphibians being known for their complex skin polypeptide secretions, only seven cathelicidins have been identified from five amphibian species. Cao et al. (2017) recently isolated a new cationic peptide, Cathelicidin-OA1, from Odorrana andersonii that possess antioxidant properties but no antimicrobial properties. Furthermore, experiments with Cathelicidin-OA1 on mouse models revealed full-thickness skin wound healing properties, which is a first for amphibian cathelicidins. Cathelicidin-OA1 promoted wound-healing by increasing macrophage recruitment to wound sites, resulting in faster skin cell production and tissue formation. These findings help us better understand this family of polypeptides and promise the development of better wound-healing agents. (Written by Ann Chang)
Written by AmphibiaWeb (amphibiaweb AT berkeley.edu), Museum of Vertebrate Zoology
First submitted 2019-08-03
Edited by Michelle Koo (2019-08-03)
Species Account Citation: AmphibiaWeb 2019 Odorrana andersonii <http://amphibiaweb.org/species/4978> University of California, Berkeley, CA, USA. Accessed Jan 26, 2020.
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Citation: AmphibiaWeb. 2020. <http://amphibiaweb.org> University of California, Berkeley, CA, USA. Accessed 26 Jan 2020.
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